Spain’s Pablo Carreno Busta reached the US Open semi-finals for the first time with a 6-4 6-4 6-2 win over 25 year old Diego Schwartzman.
The 12th seed overcame Schwartzman 6-4 6-4 6-2 in one hour and 58 minutes at the Flushing Meadows.
26 year old Carreno Busta, is the highest-ranked man left in the bottom half of the draw.
Carreno Busta is yet to drop a set at the tournament and will face Kevin Anderson in the last four.
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Anderson made his first ever Grand Slam semi-final with a 7-6(5), 6-7(9), 6-3, 7-6(7) win over American Sam Querry.
Anderson becomes the first South African to reach a US Open semifinal in the Open era by defeating Querrey.
In the women’s tournament, Venus Williams reached her 23rd Grand Slam semi-final with a thrilling win over Petra Kvitova in a final-set tie-break.
The 37-year-old won 6-3 3-6 7-6 (7-2) in front of a rapturous crowd at the Flushing Meadows.
Venus next faces Sloane Stephens in an all-American semi-final in New York.
Stephens won a final-set tie-break to beat Latvia’s Anastasija Sevastova and reach her first US Open semi-final.
The 24-year-old returned from a back injury to win 6-3 3-6 7-6 (7-4) on Tuesday.
With Madison Keys and Coco Vandeweghe also through to the last eight, there is the possibility of all-American semi-finals.
Other matches to be played today
18:30 Rafael Nadal V Andrey Rublev
17:00 Karolina Pliskova V Coco Vandeweghe
01:30 Roger Federer V Juan Martin Del Potro
00:00 Madison Keys V Kaia Kanepi